Yes, as long as you don’t provide for the creditor in your Will and the creditor is not otherwise disqualified to be a Witness.
Mississippi law provides:
“Any creditor shall be a competent subscribing witness to a last will and testament; but any special provision in favor of such creditor in the will, either by admitting the debt or by providing for its payment or by giving it a preference, shall be void, and such claim shall stand as though the provision had not been made.”